We will start by reviewing the notion of Topological Quantum Field Theory (TQFT) and its application to the study of three-manifolds and of mapping class groups. Then we will outline the properties of the "Non semi-simple TQFTs" we constructed jointly with Christian Blanchet, Nathan Geer and Bertrand Patureau. We will also discuss some of the analogies between our constructions and the recent work by Bonahon and Wong on the representations of the skein algebra of a surface.